Metabolic Syndrome Dangerous for Pregnant Mares (AAEP 2012)
by Stacey Oke, DVM, MSc
Date Posted: 2/5/2013 7:45:00 AM
Last Updated: 2/5/2013 8:00:20 AM

Equine metabolic syndrome--defined as obesity, insulin resistance, and high insulin levels circulating in the bloodstream--is a dangerous condition for any horse, but it puts pregnant mares in an especially precarious in situation. Owners and veterinarians should address metabolic syndrome and related conditions (such as laminitis and insulin resistance) in these horses to minimize risk of fetal compromise and abortion.

"During pregnancy, metabolic syndrome is a normal occurrence because it helps redirect nutrients from the mare to the developing foal," explained Peter Morresey, BVSc, MACVs, Dipl. ACT, ACVIM, of Rood & Riddle Equine Hospital, in Lexington, Ky. Problems can arise, however, if the mare already has metabolic syndrome before she is in foal. He described managing such cases in a presentation at the 2012 American Association of Equine Practitioners' Convention, held Dec 1-5 in Anaheim Calif.

"In mares that have metabolic syndrome before they become pregnant, the condition can become exacerbated," he explained Morresey. For example, mares with metabolic syndrome have alterations in insulin and lipid (good and bad fats) circulating in their bloodstream, can develop laminitis, and potentially abort the fetus.

Morresey went on to note that mares that have metabolic syndrome before becoming pregnant are generally less sensitive to the hormone insulin than their healthy counterparts, resulting in higher-than-normal blood glucose levels. To help normalize insulin dynamics during gestation, Morresey suggested owners take the following steps:

  • Feed these mares only hay or a hay substitute, remove grain and sweet feeds from their diets, and restrict their pasture access;
  • Consider exercising affected mares if laminitis is not a concern, to help control obesity; and
  • Discuss the use of metformin (an oral antidiabetic medication), L-thyroxine (a thyroid supplement), and/or pergolide (used to treat equine Cushing's disease) with your veterinarian, as these medications could benefit some horses.

"Laminitis in horses with metabolic syndrome is a major concern," Morresey advised. "Aggressive and early management of this condition (such as cryotherapy, which involves intensely cooling the horse's feet) is paramount to a successful case outcome," saving the mare.

In Morresey's opinion, "It is never too early to consult a farrier or podiatrist in the management of the laminitic insulin-resistant horse."

Veterinarians need to conduct additional research in mares with metabolic syndrome that are subsequently bred to determine the best ways to manage them throughout gestation and foaling.

Disclaimer: Seek the advice of a qualified veterinarian before proceeding with any diagnosis, treatment, or therapy.



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