Milwaukee Brew, one of only two horses to win multiple runnings of the Santa Anita Handicap (gr. I), injured an ankle during Sunday's running of the Pacific Classic (gr. I) and will not race again this year.On Aug. 26 trainer Bobby Frankel, who took over the conditioning of the son of Wild Again from Joe Orseno two years ago, pulled the horse out of the World Thoroughbred Championships Breeders' Cup Futures Bet for the Classic (gr. I). Frankel, back at Saratoga after flying to California for the Pacific Classic, said Milwaukee Brew sustained an ankle injury during the running of the race. Frankel said the horse could well be retired, but no final decision has been made.Milwaukee Brew, a 6-year-old, ran last in the four-horse field Sunday after making a strong middle move nearing the second turn. Owned by Frank Stronach's Adena Springs, Milwaukee Brew has earned $2,879,612, winning eight races from 24 lifetime starts. He became the only horse other than John Henry to take the Big 'Cap twice, capturing the 2002 and 2003 runnings. His other graded stakes triumphs came in the 2002 Californian Stakes (gr. II), the 2000 Ohio Derby (gr. II), and the 2000 Marine Stakes (gr. III) at Woodbine. He has eight other placings in graded stakes, including a third behind Volponi in last year's Breeders' Cup Classic.Milwaukee Brew was bred in Kentucky by Robert Spiegel out of the Wolf Power mare Ask Anita.